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Exposure of B cell chronic lymphocytic leukemia (B-CLL) cells to Nutlin-3 induces a characteristic gene expression profile, which correlates with Nutlin-3-mediated cytotoxicity
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How would i manage a sample submitted for flow cytometry analysis for suspicious chronic lymphocytic leukemia?
Bulian P, Del Poeta G and Gattei V. How would i manage a sample submitted for flow cytometry analysis for suspicious chronic lymphocytic leukemia? Hematol Oncol. 2009 Jul 1. [Epub ahead of print]
Samples submitted for a suspect of chronic lymphocytic leukemia are the most frequently observed in flow cytometry laboratories. These cases require not only a precise and prompt diagnosis but also an evaluation on the possibility of performing additional prognostic tests. We will propose two sequential flow cytometry panels and a personal opinion on how to manage these samples for both diagnostic and prognostic assessment, taking into account the published guidelines and recommendations.
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