Local resources

•  Exposure of B cell chronic lymphocytic leukemia (B-CLL) cells to Nutlin-3 induces a characteristic gene expression profile, which correlates with Nutlin-3-mediated cytotoxicity
•  CD38/CD31, the CCL3 and CCL4 chemokines, and CD49d/VCAM-1 are interchained by sequential events sustaining chronic lymphocytic leukemia cell survival
•  Nutlin-3 upregulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feed-back anti-apoptotic mechanism
•  How would i manage a sample submitted for flow cytometry analysis for suspicious chronic lymphocytic leukemia?
•  The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukemia and is recapitulated by biological risk factors
•  Biological and clinical risk factors of chronic lymphocytic leukaemia transformation to Richter syndrome
•  Molecular and clinical features of chronic lymphocytic leukaemia with stereotyped B cell receptors: results from an Italian multicentre study
•  Consolidation and maintenance immunotherapy with rituximab improve clinical outcome in patients with B-cell chronic lymphocytic leukemia
•  Biological and clinical risk factors of chronic lymphocytic leukaemia transformation to Richter syndrome
•  Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion
•  Are surrogates of IGHV genemutational status useful in B-cell chronic lymphocytic leukemia?
•  CD49d expression is an independent risk factor of progressive disease in early stage chronic lymphocytic leukemia
•  Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia