FEBS-SysBio2009: The 3rd FEBS Advanced Lecture Course on Systems Biology: From Molecular Biology to Biological Function
|Persona di riferimento
||Hans V. Westerhoff (Course Director)
|Indirizzo e-mail per contatti
||Ruedi Aebersold, Carole Goble, Bela Novak, Philippe Bastiaens, Igor Goryanin, Jaroslav Stark, Jean Beggs, Adriano Henney, Peter Tass, Roger Brent, Stefan Hohmann, Bas Teusink, Carsten Carlberg, Boris Kholodenko, Ron Weiss, David de Graaf, Ursula Klingmüller, Mike White, David Fell, Sang Yup Lee, James Ferrell, Erik Mosekilde
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Systems Biology is one of the most prominent newly emerging interdisciplinary science areas. By connecting fields such as genomics, proteomics, cell biology, medicine, molecular biology, biochemistry and genetics, with mathematics, bioinformatics, engineering and computation, it enables discovery of yet unknown principles underlying the functioning of living cells. At the same time testable and predictive models of complex cellular pathways and eventually of whole cells are generated, which are useful for efficient experimental design and bioengineering and the network-based design of drugs and therapies. FEBSSysBio2009 will cover essential and state-of-the-art aspects of SysBio from principles and methods through the modeling of living systems to applications in biotechnology and medicine.
Symposium 1: Foundations of Systems Biology
(Chair - Erik Mosekilde)
C Goble, R Aebersold, U Sauer
Systems Biology depends on Mathematics, Physics and Chemistry on the one hand, but also on fundamental Biology, Biochemistry and Molecular Genetics. In addition it has its own principles, such as those of emergence, self-organization, heterogeneous dynamics, nonlinear stochastics, hysteresis and robustness. Furthermore, it has its own methodologies, or modifications of existing methodologies that are essential for systems biology. It is these methodological foundations that are the focus of this symposium.
Symposium 2: Systems Biology in Space
(Chair - Hans Westerhoff)
P Bastiaens, M White, B Kholodenko
Until now most of Systems Biology has focused on describing biochemical, gene expression or signal transduction networks in terms of changes in cell-wide concentrations with time. Less attention has been paid to the fact that these processes are also occurring in space. This symposium will address how movement of molecules through the cell is important for biological function and how microscopic structures influence non spatial processes.
Symposium 3: The proof of the pudding
(Chair - Uwe Sauer)
E Klipp, S Hohmann, J Beggs, I Goryanin, R Brent
The topics of this symposium are the experimental validations of principles discovered by theoretical Systems Biology, as well as demonstrating that Systems Biology is a worthy new science and showing that Systems Biology can actually deliver something more than traditional sciences.
Symposium 4: The dynamic genome
(Chair - Frank Bruggeman)
C Carlberg, J Ferrell, B Novak
There are nice models in which repressor proteins bind to inducers and then drop off the DNA to give way to RNA polymerase. Somehow this model is not sufficient for understanding gene-expression regulation. The genetic material itself dos not seem to be constant. It can be supercoiled, brought into active or inactive states though interactions with DNA binding proteins, which may in turn be modified covalently. This then may lead to epigenetic effects. Systems Biology will soon play an important role here, as many dynamic processes concur at various scales in the dimensions of time, space and chemistry.
Symposium 5: Making Systems Biology work
(Chair – Adriano Henney)
R Weiss, D de Graaf, P Tass, S-Y Lee
Most of the diseases of mankind today are multifactorial. Thereby they tend to escape the therapies that target single molecules. The same issue limits the success of metabolic engineering. It is a new kind of, Systems Biology minded, engineering that should now produce progress. This symposium will highlight the new systems methodologies.
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